Double helical structure of DNA molecule:
DNA is mainly found in the
nucleus. A small amount of DNA is also found in mitochondria and chloroplast.
It a macromolecule formed by the end to end polymerization of a large number of
repeated units called deoxyribonucleotides or simply nucleotides.
Each nucleotide is formed by
cross-linking of three substances:
i.
Deoxyribose
Sugar: The DNA molecules contain deoxyribose sugar and hence, it is called
deoxyribo nucleic acid. Deoxyribose is a pentose sugar (with 5-carbon atoms).
ii.
Phosphate:
The phosphate in the DNA is present as phosphoric acid (H3PO4).
Each phosphate group is joined to a carbon atom 3’ of one deoxyribose sugar and
to carbon atom 5’ of another deoxyribose sugar.
iii.
Nitrogenous
Bases: The nitrogenous bases are of two types: Purine and Pyrimidine.
a)
Purine:
It is a double ringed structure. It contains Adenine (A) and Guanine (G).
b)
Pyrimidine:
It is a single ringed structure. It contains Cytosine (C) and Thymine (T).
Nucleotides and nucleosides:
A sugar molecule with nitrogenous
base forms a nucleotide. The nucleosides in DNA are called deoxyribonucleosides and nucleotides are called deoxyribonucleotides.
Nitrogenous base + sugar=
Nucleoside
Nucleoside + phosphate=
Nucleotide
Or
Nitrogenous base + sugar +phosphate=
Nucleotide
DNA is a double helix or double stranded
structures. By definition of a helix:
Double helix: The structure of DNA with the two strands of DNA spiraling about one other.
The double helix looks something like an immensely long ladder twisted into a helix, or coil. The sides of the "ladder" are formed by a backbone of sugar and phosphate molecules, and the "rungs" consist of nucleotide bases joined weakly in the middle by hydrogen bonds.
Double helix: The structure of DNA with the two strands of DNA spiraling about one other.
The double helix looks something like an immensely long ladder twisted into a helix, or coil. The sides of the "ladder" are formed by a backbone of sugar and phosphate molecules, and the "rungs" consist of nucleotide bases joined weakly in the middle by hydrogen bonds.
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